Understanding Chewable Sildenafil Formulations

Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical Interventions in Aging, 1(4), 403-414. B., Storey, A., Cartledge, J., & Eardley, I.

Warnings & Precautions

Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors. Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5 mg and 10 mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Annals of Pharmacotherapy, 38(1), 77-85. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. International Journal of Occupational and Environmental Health, 22(1), 7-17.

What are the Potential Side Effects of Sildenafil (SIL)?

Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency? Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study. Applies to sildenafil: oral powder for suspension, oral suspension, oral tablet. If you take sildenafil for pulmonary arterial hypertension, do not take Viagra® or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). Sildenafil should not be used with any other medicine or device that causes erections.

Sildenafil and Viagra pills may look different

Some side effects of sildenafil may occur that usually do not need medical attention. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Along with its needed effects, sildenafil may cause some unwanted effects. Check with your doctor immediately if any of the following side effects occur while taking sildenafil: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Applies to sildenafil: intravenous solution, oral film, oral powder for reconstitution, oral tablet. The most common adverse reactions occurring in patients with erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) included headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, rash, visual disturbance, cyanopsia, blurred vision, limb pain, priapism, upper respiratory infection, vomiting, bronchitis, pharyngitis, pyrexia, diarrhea, influenza, epistaxis. Very common (10% or more): Flushing (up to 19%) Rare (0.01% to 0.1%): Myocardial infarction, atrial fibrillation, unstable angina, tachycardia, palpitations Frequency not reported: Shock, angina pectoris, AV block, migraine, syncope, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, vasodilation, abnormal electrocardiogram, increased heart rate Postmarketing reports: Myocardial infarction, sudden cardiac death, cardiac arrest, ventricular arrhythmia, hypertension, hypotensive events after the use with alpha-blockers, tachycardia, hypotension, syncope Very common (10% or more): Dyspepsia (up to 17%), diarrhea Common (1% to 10%): Nausea, vomiting, dry mouth, gastritis, gastroesophageal reflux disease, hemorrhoids, abdominal distension Rare (less than 0.1%): Oral hypoesthesia Frequency not reported: Glossitis, colitis, dysphagia, gastroenteritis, esophagitis, stomatitis, gingivitis Very common (10% or more): Pain in limb (up to 15%), myalgia (up to 14%), back pain (up to 13%) Frequency not reported: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis Postmarketing reports: Pain in extremity, pain in jaw, arthralgia Very common (10% or more): Headache (up to 28% in ED; up to 49% in PAH) Common (1% to 10%): Dizziness, vertigo, paresthesia, tremor, burning sensation, migraine, hypoesthesia Rare (0.01% to 0.1%): Cerebrovascular accident, transient ischemic attack, syncope Frequency not reported: Ataxia, hypertonia, neuralgia, neuropathy, vertigo, depression, decreased reflexes/hyporeflexia, cerebral thrombosis, convulsion Postmarketing reports: Cerebrovascular hemorrhage, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, seizure, seizure recurrence, transient global amnesia Very common (10% or more): Abnormal vision (up to 11%) Common (1% to 10%): Abnormal sensation in eye, chromatopsia, cyanopsia, diplopia, eye irritation, photophobia, retinal hemorrhage, visual acuity reduced, visual color distortion Uncommon (0.1% to 1%): Dry eye, lacrimal disorder, photopsia, ocular hyperemia, visual brightness, conjunctivitis, eye pain Rare (0.01% to 0.1%): Arteriosclerotic retinopathy, retinal disorder, glaucoma, visual field defect, myopia, asthenopia, vitreous floaters, iris disorder, mydriasis, halo vision, eye edema, eye swelling, eye disorder, conjunctival hyperemia, eyelid edema, scleral discoloration Frequency not reported: Eye hemorrhage, cataract, visual disturbance, xanthopsia, erythropsia Postmarketing reports: Diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal edema, retinal vascular disease or bleeding, vitreous traction/detachment, non-arteritic anterior ischemic optic neuropathy (NAION) Abnormal vision included a severity that was mild to moderate and transient, characterized predominantly by color tinge to vision, but also increased sensitivity to light, or blurred vision. Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues. Part B, Critical Reviews, 16(7), 399-451. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats. Journal of Toxicology and Environmental Health, Part A, 71(21), 1415–1429. Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports.

Other Options

Lacrimation disorders included dry eye, lacrimal disorder, and lacrimation increased. Very common (10% or more): Upper respiratory tract infection (up to 31%), bronchitis (up to 20%), pharyngitis (up to 18%) Common (1% to 10%): Nasal congestion, cough, epistaxis, dyspnea, sinusitis, rhinitis, bronchitis, pneumonia, rhinorrhea Uncommon (0.1% to 1%): Sinus congestion Frequency not reported: Asthma, laryngitis, increased sputum, increased cough, respiratory tract infection, throat tightness, nasal dryness, nasal edema, bronchopneumonia, hypoxia, stridor, pulmonary hypertension Common (1% to 10%): Rash, erythema, alopecia Frequency not reported: Face edema, photosensitivity reaction, urticaria, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis Postmarketing reports: Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) Postmarketing reports: Vaso-occlusive crisis (in patients with PAH secondary to sickle cell disease) Common (1% to 10%): Increased weight, fluid retention Frequency not reported: Edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia Very common (10% or more): Pyrexia (up to 17%), influenza (up to 12%) Common (1% to 10%): Cellulitis, gynecomastia, breast enlargement, night sweats Uncommon (0.1% to 1%): Tinnitus, chest pain, feeling hot, fatigue Rare (0.01% to 0.1%): Deafness, irritability Frequency not reported: Asthenia, pain, chills, accidental fall, accidental injury, thirst, sudden decrease or loss of hearing, ear pain, flu syndrome, infection, herpes simplex Postmarketing reports: Sudden decrease or loss of hearing Common (1% to 10%): Increased erection, urinary tract infection Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia Frequency not reported: Cystitis, nocturia, urinary frequency, urinary incontinence, abnormal ejaculation, genital edema, anorgasmia, prostatic disorder Pfizer U.S. Pharmaceuticals Group, SUPPL-25 Cialis vs Viagra - What's the difference between them? Do you know these 11 amazing facts about Viagra? Is generic Viagra available in the U.S.?

Who should not take sildenafil?

Sildenafil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide. Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential. The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives.

Xylitol: A Review on Bioproduction, Application, Health Benefits, and Related Safety Issues. Critical Reviews in Food Science and Nutrition, 55(11), 1514–1528.

More about sildenafil

Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clinical Interventions in Aging, 1(4), 403-414. B., Storey, A., Cartledge, J., & Eardley, I. Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors. Evaluation of the Efficacy and Safety of Once-a-Day Dosing of Tadalafil 5 mg and 10 mg in the Treatment of Erectile Dysfunction: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Altitude sickness

Annals of Pharmacotherapy, 38(1), 77-85. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. International Journal of Occupational and Environmental Health, 22(1), 7-17. Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues. Part B, Critical Reviews, 16(7), 399-451. Toxicological effects of Mentha x piperita liquid sildenafil citrate (peppermint): a review. Phosphodiesterase-5 (PDE-5) Inhibitors and Ototoxicity: A Systematic Review.

• Sildenafil enhances natural erectile responses with proper use.
• Chewing sildenafil is discouraged because it may cause irritation.
• Follow dosing guidelines strictly to avoid complications.
• Sildenafil is effective but not a cure for all causes of ED.
• Take sildenafil at the same time each day if prescribed regularly.
• Be cautious about using sildenafil with concomitant medications.
• Keep sildenafil out of sun and moisture to preserve quality.
• Side effects may diminish over time with continued use.
• Always consult a healthcare provider for personalized advice.

Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency? Folic acid supplementation improves erectile function in patients with idiopathic vasculogenic erectile dysfunction by lowering peripheral and penile homocysteine plasma levels: a case-control study. Applies to sildenafil: oral powder for suspension, oral suspension, oral tablet.

• Sildenafil works by relaxing blood vessels in the penis.
• Chewing sildenafil might cause a faster onset of action.
• Crushing sildenafil tablets can affect its efficacy and safety.
• Sildenafil is not meant to be chewed, broken, or crushed.
• Use sildenafil as directed by a doctor for optimal results.
• Be aware that chewing sildenafil can increase side effects.
• Sildenafil is available by prescription only in many countries.
• Avoid taking sildenafil with heavy meals or high-fat foods.
• Inform your doctor of any medications you are taking before using sildenafil.

If you take sildenafil for pulmonary arterial hypertension, do not take Viagra® or other PDE5 inhibitors, including tadalafil (Cialis®) or vardenafil (Levitra®). Sildenafil should not be used with any other medicine or device that causes erections. Some side effects of sildenafil may occur that usually do not need medical attention.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Along with its needed effects, sildenafil may cause some unwanted effects. Check with your doctor immediately if any of the following side effects occur while taking sildenafil: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Applies to sildenafil: intravenous solution, oral film, oral powder for reconstitution, oral tablet.

The most common adverse reactions occurring in patients with erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) included headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, rash, visual disturbance, cyanopsia, blurred vision, limb pain, priapism, upper respiratory infection, vomiting, bronchitis, pharyngitis, pyrexia, diarrhea, influenza, epistaxis. Very common (10% or more): Flushing (up to 19%) Rare (0.01% to 0.1%): Myocardial infarction, atrial fibrillation, unstable angina, tachycardia, palpitations Frequency not reported: Shock, angina pectoris, AV block, migraine, syncope, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, vasodilation, abnormal electrocardiogram, increased heart rate Postmarketing reports: Myocardial infarction, sudden cardiac death, cardiac arrest, ventricular arrhythmia, hypertension, hypotensive events after the use with alpha-blockers, tachycardia, hypotension, syncope Very common (10% or more): Dyspepsia (up to 17%), diarrhea Common (1% to 10%): Nausea, vomiting, dry mouth, gastritis, gastroesophageal reflux disease, hemorrhoids, abdominal distension Rare (less than 0.1%): Oral hypoesthesia Frequency not reported: Glossitis, colitis, dysphagia, gastroenteritis, esophagitis, stomatitis, gingivitis Very common (10% or more): Pain in limb (up to 15%), myalgia (up to 14%), back pain (up to 13%) Frequency not reported: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis Postmarketing reports: Pain in extremity, pain in jaw, arthralgia Very common (10% or more): Headache (up to 28% in ED; up to 49% in PAH) Common (1% to 10%): Dizziness, vertigo, paresthesia, tremor, burning sensation, migraine, hypoesthesia Rare (0.01% to 0.1%): Cerebrovascular accident, transient ischemic attack, syncope Frequency not reported: Ataxia, hypertonia, neuralgia, neuropathy, vertigo, depression, decreased reflexes/hyporeflexia, cerebral thrombosis, convulsion Postmarketing reports: Cerebrovascular hemorrhage, transient ischemic attack, subarachnoid hemorrhage, intracerebral hemorrhage, seizure, seizure recurrence, transient global amnesia Very common (10% or more): Abnormal vision (up to 11%) Common (1% to 10%): Abnormal sensation in eye, chromatopsia, cyanopsia, diplopia, eye irritation, photophobia, retinal hemorrhage, visual acuity reduced, visual color distortion Uncommon (0.1% to 1%): Dry eye, lacrimal disorder, photopsia, ocular hyperemia, visual brightness, conjunctivitis, eye pain Rare (0.01% to 0.1%): Arteriosclerotic retinopathy, retinal disorder, glaucoma, visual field defect, myopia, asthenopia, vitreous floaters, iris disorder, mydriasis, halo vision, eye edema, eye swelling, eye disorder, conjunctival hyperemia, eyelid edema, scleral discoloration Frequency not reported: Eye hemorrhage, cataract, visual disturbance, xanthopsia, erythropsia Postmarketing reports: Diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal edema, retinal vascular disease or bleeding, vitreous traction/detachment, non-arteritic anterior ischemic optic neuropathy (NAION) Abnormal vision included a severity that was mild to moderate and transient, characterized predominantly by color tinge to vision, but also increased sensitivity to light, or blurred vision.

How long does SIL last?

Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats. Journal of Toxicology and Environmental Health, Part A, 71(21), 1415–1429. Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports. Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential.

Are you currently using Sildenafil (Viagra, Revatio)?

The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives. Xylitol: A Review on Bioproduction, Application, Health Benefits, and Related Safety Issues. Critical Reviews in Food Science and Nutrition, 55(11), 1514–1528. Toxicological effects of Mentha x piperita liquid sildenafil citrate (peppermint): a review. Phosphodiesterase-5 (PDE-5) Inhibitors and Ototoxicity: A Systematic Review. Lacrimation disorders included dry eye, lacrimal disorder, and lacrimation increased. Very common (10% or more): Upper respiratory tract infection (up to 31%), bronchitis (up to 20%), pharyngitis (up to 18%) Common (1% to 10%): Nasal congestion, cough, epistaxis, dyspnea, sinusitis, rhinitis, bronchitis, pneumonia, rhinorrhea Uncommon (0.1% to 1%): Sinus congestion Frequency not reported: Asthma, laryngitis, increased sputum, increased cough, respiratory tract infection, throat tightness, nasal dryness, nasal edema, bronchopneumonia, hypoxia, stridor, pulmonary hypertension Common (1% to 10%): Rash, erythema, alopecia Frequency not reported: Face edema, photosensitivity reaction, urticaria, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis Postmarketing reports: Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) Postmarketing reports: Vaso-occlusive crisis (in patients with PAH secondary to sickle cell disease) Common (1% to 10%): Increased weight, fluid retention Frequency not reported: Edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia Very common (10% or more): Pyrexia (up to 17%), influenza (up to 12%) Common (1% to 10%): Cellulitis, gynecomastia, breast enlargement, night sweats Uncommon (0.1% to 1%): Tinnitus, chest pain, feeling hot, fatigue Rare (0.01% to 0.1%): Deafness, irritability Frequency not reported: Asthenia, pain, chills, accidental fall, accidental injury, thirst, sudden decrease or loss of hearing, ear pain, flu syndrome, infection, herpes simplex Postmarketing reports: Sudden decrease or loss of hearing Common (1% to 10%): Increased erection, urinary tract infection Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia Frequency not reported: Cystitis, nocturia, urinary frequency, urinary incontinence, abnormal ejaculation, genital edema, anorgasmia, prostatic disorder Pfizer U.S. Pharmaceuticals Group, SUPPL-25 Cialis vs Viagra - What's the difference between them? Do you know these 11 amazing facts about Viagra? Is generic Viagra available in the U.S.? Sildenafil side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.